Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphoma
نویسندگان
چکیده
منابع مشابه
Lymphocytosis: T-cell large granular lymphocyte leukemia.
A 50-year-old female with low-grade chronic anemia and no other medical problems was evaluated when her hemoglobin fell to 8.2 g/dL. She had no adenopathy or hepatosplenomegaly. Her white cell count was 7.7 109/L with a lymphocyte count of 6.2 109/L, platelets 498 109/L, and reticulocyte count that was normal. Serum electrophoresis and rheumatoid factor were negative and ANA was weakly positive...
متن کاملT-cell lymphoma 504 THE CLINICAL SPECTRUM OF LARGE GRANULAR LYMPHOCYTIC LEUKAEMIA: A CASE SERIES
*co first author Large Granular Lymphocytic Leukaemia (LGL) is an indolent T lymphoproliferative disorder. Molecular analysis of the T cell receptor (TCR) gene to define clonal T populations has made LGL diagnosis robust and clarified its natural history. We confirm the indolent presentation but highlight the ultimate requirement for therapy. Fifteen patients, aged between 44 and 78 were referr...
متن کاملAssociation of pure red cell aplasia with T large granular lymphocyte leukaemia.
AIM To define the relation between T large granular lymphocyte (T-LGL) leukaemia and pure red cell aplasia in Chinese patients. METHODS Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leukaemia was based on typical morphological and immunophenotypical features, and confirmed by the d...
متن کاملMalignant transformation of T-cell large granular lymphocyte leukemia in a dog.
An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes. Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chro...
متن کاملLow-dose methotrexate in PAH related to T-cell large granular lymphocyte leukaemia.
T-cell large granular lymphocytes (LGLs) are a morphologically distinct subset of normal peripheral blood mononuclear cells classified into two major lineages based on the presence of the CD3 receptor: CD3+ lymphocytes and CD3natural killer cells. The revised European-American classification of lymphoid neoplasms [2] considers clonal proliferation of these cells, or LGL leukaemia (as proved by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2001
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2001.03220.x